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Gene Expression in Placentas From Nondiabetic Women Giving Birth to Large for Gestational Age Infants
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Obstetrik & gynekologi. Univ Groningen, Dept Behav Physiol, Groningen, Netherlands.;Karolinska Inst, Ctr Gender Med, Stockholm, Sweden..
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2015 (engelsk)Inngår i: Reproductive Sciences, ISSN 1933-7191, E-ISSN 1933-7205, Vol. 22, nr 10, s. 1281-1288Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Gestational diabetes, obesity, and excessive weight gain are known independent risk factors for the birth of a large for gestational age (LGA) infant. However, only 1 of the 10 infants born LGA is born by mothers with diabetes or obesity. Thus, the aim of the present study was to compare placental gene expression between healthy, nondiabetic mothers (n = 22) giving birth to LGA infants and body mass index-matched mothers (n = 24) giving birth to appropriate for gestational age infants. In the whole gene expression analysis, only 29 genes were found to be differently expressed in LGA placentas. Top upregulated genes included insulin-like growth factor binding protein 1, aminolevulinate synthase 2, and prolactin, whereas top downregulated genes comprised leptin, gametocyte-specific factor 1, and collagen type XVII 1. Two enriched gene networks were identified, namely, (1) lipid metabolism, small molecule biochemistry, and organismal development and (2) cellular development, cellular growth, proliferation, and tumor morphology.

sted, utgiver, år, opplag, sider
2015. Vol. 22, nr 10, s. 1281-1288
Emneord [en]
large for gestational age, placental gene expression, microarray, leptin, and prolactin
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Identifikatorer
URN: urn:nbn:se:uu:diva-264615DOI: 10.1177/1933719115578928ISI: 000361530300012PubMedID: 25824011OAI: oai:DiVA.org:uu-264615DiVA, id: diva2:865290
Forskningsfinansiär
Swedish Society for Medical Research (SSMF)Tilgjengelig fra: 2015-10-27 Laget: 2015-10-15 Sist oppdatert: 2017-12-01bibliografisk kontrollert

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Ahlsson, FredrikAkerud, HelenaOlivier, JocelienSundström Poromaa, Inger

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