uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Chemical modification of Cladophora nanocellulose to provide a non-toxic material with anticoagulant properties
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanoteknologi och funktionella material)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanotechnology and Functional Materials)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanotechnology and Functional Materials)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material. (Nanoteknologi och funktionella material)ORCID-id: 0000-0002-5496-9664
Vise andre og tillknytning
2015 (engelsk)Konferansepaper, Poster (with or without abstract) (Fagfellevurdert)
Abstract [en]

Blood purification is a common procedure for treating patients with kidney failure in which an extracorporeal device filled with a porous material containing antibodies can retain toxins from the blood. In order to avoid activation and coagulation, heparin is administrated to patients; however this sulfonated polysaccharide may cause many side effects such as intense bleeding and osteoporosis. In this project nanocellulose from Cladophora green algae was used for the development of a porous material with anticoagulant properties. A periodate oxidation followed by an amine cross-linking and subsequent reduction produced dialdehyde cellulose beads ranging from 10-100 mm in diameter with improved mechanical properties and high stability in alkaline media. This material was then sulfonated to acquire anticoagulant properties and characterized by FTIR, z-potential, condutometric titration, elemental analysis and BET surface area showing that its porosity varies with the degree of sulfonation. After extensive washing, toxicology experiments were performed with a THP-1 monocyte cell line in order to examine if the material was non-toxic and could be suitable as a matrix in blood purification.

sted, utgiver, år, opplag, sider
2015.
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-266842OAI: oai:DiVA.org:uu-266842DiVA, id: diva2:868895
Konferanse
4th International Polysaccharide Conference (EPNOE 2015), Warsaw, Poland,19-22 October 2015
Tilgjengelig fra: 2015-11-12 Laget: 2015-11-12 Sist oppdatert: 2016-11-30bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Personposter BETA

Rocha, IgorFerraz, NataliaMihranyan, AlbertStrömme, MariaLindh, Jonas

Søk i DiVA

Av forfatter/redaktør
Rocha, IgorFerraz, NataliaMihranyan, AlbertStrömme, MariaLindh, Jonas
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 416 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf