Manufacturing doubt about endocrine disrupter science - A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012"Univ Pretoria, Sch Hlth Syst & Publ Hlth, ZA-0002 Pretoria, South Africa..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Miljötoxikologi.
Univ Calif Irvine, Irvine, CA USA..
Vancouver Aquarium Marine Sci Ctr, Vancouver, BC, Canada..
Univ Calif San Francisco, San Francisco, CA 94143 USA..
Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA..
Natl Inst Basic Biol, Okazaki, Aichi 444, Japan..
Brunel Univ London, Uxbridge, Middx, England..
Univ New Brunswick, New Brunswick, NJ USA..
Brunel Univ London, Uxbridge, Middx, England..
Environm Canada, Burlington, ON L7R 4A6, Canada..
Aga Khan Univ Hosp, Nairobi, Kenya..
Norwegian Univ Life Sci, Oslo, Norway..
Vancouver Aquarium Marine Sci Ctr, Vancouver, BC, Canada..
Univ Copenhagen, Copenhagen Univ Hosp, Copenhagen, Denmark..
Univ Turku, Turku, Finland..
Univ Massachusetts, Amherst, MA 01003 USA..
Univ Calif San Francisco, San Francisco, CA 94143 USA..
Univ Massachusetts, Amherst, MA 01003 USA..
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2015 (Engelska)Ingår i: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 73, nr 3, s. 1007-1017Artikel i tidskrift, Editorial material (Övrigt vetenskapligt) Published
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Abstract [en]
We present a detailed response to the critique of "State of the Science of Endocrine Disrupting Chemicals 2012" (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013) report is not particularly erudite and that their critique is not intended to be convincing to the scientific community, but to confuse the scientific data. Consequently, it promotes misinterpretation of the UNEP/WHO (2013) report by non-specialists, bureaucrats, politicians and other decision makers not intimately familiar with the topic of endocrine disruption and therefore susceptible to false generalizations of bias and subjectivity.
Ort, förlag, år, upplaga, sidor
2015. Vol. 73, nr 3, s. 1007-1017
Nyckelord [en]
Endocrine disruption, EDCs, Endocrine disruptors
Nationell ämneskategori
Farmakologi och toxikologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:uu:diva-280181DOI: 10.1016/j.yrtph.2015.07.026ISI: 000367279400042PubMedID: 26239693OAI: oai:DiVA.org:uu-280181DiVA, id: diva2:910303
2016-03-082016-03-082018-01-10Bibliografiskt granskad