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Cerebral blood flow during anticipation of public speaking in social phobia: a PET study.
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. (Psychiatry, University Hospital)
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
2002 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 52, nr 11, s. 1113-1119Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND

The aim was to examine the neural correlates of anxiety elicited by the anticipation of public speaking in individuals with social phobia. Positron emission tomography and (15)O-water was used to measure regional cerebral blood flow in subjects with DSM-IV defined social phobia during anxiety anticipation. Heart rate and subjective anxiety were also recorded. While being scanned, subjects were speaking alone either before or after speaking in public. To evaluate anticipatory anxiety we compared individuals speaking alone before they were speaking in front of an audience with those who did the reverse.

RESULTS

Heart rate and subjective anxiety measures confirmed anticipatory anxiety in social phobics who performed their private speech before their public. This was accompanied by enhanced cerebral blood flow in the right dorsolateral prefrontal cortex, left inferior temporal cortex, and in the left amygdaloid-hippocampal region. Brain blood flow was lower in the left temporal pole and bilaterally in the cerebellum in the anticipation group.

CONCLUSIONS

Brain regions with altered perfusion presumably reflect changes in neural activity associated with worry about anticipated public performance. We speculate that anticipatory anxiety in social phobics originates in an affect sensitive fear network encompassing the amygdaloid-hippocampal region, prefrontal, and temporal areas.

Ort, förlag, år, upplaga, sidor
2002. Vol. 52, nr 11, s. 1113-1119
Nyckelord [en]
Anticipatory anxiety, social phobia, public speaking, induced anxiety, positron emission tomography, regional cerebral blood flow
Identifikatorer
URN: urn:nbn:se:uu:diva-64887PubMedID: 12460694OAI: oai:DiVA.org:uu-64887DiVA, id: diva2:92798
Tillgänglig från: 2008-06-14 Skapad: 2008-06-14 Senast uppdaterad: 2017-11-30Bibliografiskt granskad

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Furmark, TomasMarteinsdottir, InaFredriksson, Mats

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