uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Endometrial transcriptome analysis indicates superiority of natural over artificial cycles in recurrent implantation failure patients undergoing frozen embryo transfer
Competence Ctr Hlth Technol, Tartu, Estonia.;Univ Granada, Sch Med, Dept Paediat, Granada, Spain..
Tallinn Univ Technol, Dept Gene Technol, EE-19086 Tallinn, Estonia..
Univ Jaen, Dept Expt Biol, Jaen, Spain..
Tallinn Univ Technol, Dept Gene Technol, EE-19086 Tallinn, Estonia..
Vise andre og tillknytning
2016 (engelsk)Inngår i: Reproductive Biomedicine Online, ISSN 1472-6483, E-ISSN 1472-6491, Vol. 32, nr 6, s. 597-613Artikkel i tidsskrift (Fagfellevurdert) Published
Resurstyp
Text
Abstract [en]

Little consensus has been reached on the best protocol for endometrial preparation for frozen embryo transfer (FET). It is not known how, and to what extent, hormone supplementation in artificial cycles influences endometrial preparation for embryo implantation at a molecular level, especially in patients who have experienced recurrent implantation failure. Transcriptome analysis of 15 endometrial biopsy samples at the time of embryo implantation was used to compare two different endometrial preparation protocols, natural versus artificial cycles, for FET in women who have experienced recurrent implantation failure compared with fertile women. IPA and DAVID were used for functional analyses of differentially expressed genes. The TRANSFAC database was used to identify oestrogen and progesterone response elements upstream of differentially expressed genes. Cluster analysis demonstrated that natural cycles are associated with a better endometrial receptivity transcriptome than artificial cycles. Artificial cycles seemed to have a stronger negative effect on expression of genes and pathways crucial for endometrial receptivity, including ESR2, FSHR, LEP, and several interleukins and matrix metalloproteinases. Significant overrepresentation of oestrogen response elements among the genes with deteriorated expression in artificial cycles (P < 0.001) was found; progesterone response elements predominated in genes with amended expression with artificial cycles (P = 0.0052).

sted, utgiver, år, opplag, sider
2016. Vol. 32, nr 6, s. 597-613
Emneord [en]
artificial cycle, endometrial receptivity, frozen embryo transfer, hormone response elements, recurrent implantation failure, unexplained female infertility
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-299501DOI: 10.1016/j.rbmo.2016.03.004ISI: 000377393600006PubMedID: 27090967OAI: oai:DiVA.org:uu-299501DiVA, id: diva2:949697
Forskningsfinansiär
EU, European Research Council, 329812EU, FP7, Seventh Framework Programme, EU41564;EU324509Tilgjengelig fra: 2016-07-22 Laget: 2016-07-22 Sist oppdatert: 2017-11-28bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Stavreus-Evers, Anneli

Søk i DiVA

Av forfatter/redaktør
Stavreus-Evers, Anneli
Av organisasjonen
I samme tidsskrift
Reproductive Biomedicine Online

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 653 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf