Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study
2005 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 113, no 2, 126-134 p.Article in journal (Refereed) Published
Sweden is an area potentially endemic for spotted fever rickettsioses. Rickettsia helvetica has been isolated from its tick vector Ixodes Ricinus, and in a handful of cases linked to human disease. This study demonstrates for the first time in Sweden the transmission of rickettsial infection after a tick bite and the attack rate in an endemic area. We present three cases of documented rickettsial infection and a prospective serological study of Swedish recruits who were trained in the area where the patients lived and showed seroconversion to spotted fever rickettsiae. All patients showed a four-fold increas in antibody titer to the spotted fever rickettsia, R. helvetica, and immunohistochemical examination revealed rickettsia-like organisms in the walls of skin capillaries and veins. Electron microscopy showed organisms resembling R. helvetica and immunogold labeling with two anti-rickettsial antibodies demonstrated specific labeling of the rickettsial organisms in the skin biopsy specimens. Eight of the thirty-five recruits showed a four-fold increase in IgG titer reflecting a high rate of exposure. The results of this study demonstrate that spotted fever rickettsioses should be taken into consideration in the diagnosis of tick-transmitted infections in Sweden.
Place, publisher, year, edition, pages
2005. Vol. 113, no 2, 126-134 p.
Rickettsiosis, serology, ultrastructure, tick
Rickettsios, serologi, ultrastruktur, fästingar
Dermatology and Venereal Diseases
IdentifiersURN: urn:nbn:se:uu:diva-72248DOI: 10.1111/j.1600-0463.2005.apm1130206.xPubMedID: 15723687OAI: oai:DiVA.org:uu-72248DiVA: diva2:100159