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Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Center for Clinical Research Dalarna. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2005 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 113, no 2, 126-134 p.Article in journal (Refereed) Published
Abstract [en]

Sweden is an area potentially endemic for spotted fever rickettsioses. Rickettsia helvetica has been isolated from its tick vector Ixodes Ricinus, and in a handful of cases linked to human disease. This study demonstrates for the first time in Sweden the transmission of rickettsial infection after a tick bite and the attack rate in an endemic area. We present three cases of documented rickettsial infection and a prospective serological study of Swedish recruits who were trained in the area where the patients lived and showed seroconversion to spotted fever rickettsiae. All patients showed a four-fold increas in antibody titer to the spotted fever rickettsia, R. helvetica, and immunohistochemical examination revealed rickettsia-like organisms in the walls of skin capillaries and veins. Electron microscopy showed organisms resembling R. helvetica and immunogold labeling with two anti-rickettsial antibodies demonstrated specific labeling of the rickettsial organisms in the skin biopsy specimens. Eight of the thirty-five recruits showed a four-fold increase in IgG titer reflecting a high rate of exposure. The results of this study demonstrate that spotted fever rickettsioses should be taken into consideration in the diagnosis of tick-transmitted infections in Sweden.

Place, publisher, year, edition, pages
2005. Vol. 113, no 2, 126-134 p.
Keyword [en]
Rickettsiosis, serology, ultrastructure, tick
Keyword [sv]
Rickettsios, serologi, ultrastruktur, fästingar
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:uu:diva-72248DOI: 10.1111/j.1600-0463.2005.apm1130206.xPubMedID: 15723687OAI: oai:DiVA.org:uu-72248DiVA: diva2:100159
Available from: 2006-06-22 Created: 2006-06-22 Last updated: 2017-12-14Bibliographically approved

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Nilsson, KennethLukinius, AgnetaPåhlson, CarlLindquist, Olle

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Center for Clinical Research DalarnaDepartment of Medical SciencesDepartment of Genetics and Pathology
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Dermatology and Venereal Diseases

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