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Little difference between minimum inhibitory concentrations of Mycobacterium tuberculosis wild-type organisms determined with BACTEC MGIT 960 and Middlebrook 7H10
Lund Univ, Dept Lab Med, Med Microbiol, Lund, Sweden..
MTC Karolinska Inst, Karolinska Univ Hosp, Clin Microbiol, Stockholm, Sweden.;Univ West Indies, Dept Microbiol, Kingston, Jamaica..
Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden..
Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden..
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2015 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 21, no 2, 148.e5Article in journal (Refereed) Published
Abstract [en]

The MIC wild-type (WT) distribution for Mycobacterium tuberculosis in BACTEC 960 MGIT is not defined, which may result in poor reproducibility for drug susceptibility testing (DST), as several DST methods with different breakpoints are in use. In a comparison between MGIT and Middlebrook 7H10 medium of seven first-and second-line drugs, including 133 MIC determinations of 15 WT isolates, we found an agreement of 91.7% within +/- one MIC dilution step. The results confirm the agreement in MIC testing between 7H10 and MGIT and indicate that breakpoints could be harmonized in order to avoid misclassification. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2015. Vol. 21, no 2, 148.e5
Keyword [en]
Drug susceptibility testing, epidemiological cut off, minimal inhibitory concentration, normalised resistance
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-303583DOI: 10.1016/j.cmi.2014.08.021ISI: 000381514200006OAI: oai:DiVA.org:uu-303583DiVA: diva2:1001970
Available from: 2016-09-30 Created: 2016-09-20 Last updated: 2016-09-30Bibliographically approved

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