Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease
2003 (English)In: Brain Research. Molecular Brain Research, ISSN 0169-328X, Vol. 116, no 1-2, 155-158 p.Article in journal (Refereed) Published
Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.
Place, publisher, year, edition, pages
2003. Vol. 116, no 1-2, 155-158 p.
Alzheimer Disease/*enzymology/genetics/metabolism, Amyloid beta-Protein Precursor/analysis/genetics, Comparative Study, Endopeptidases/genetics/*metabolism, Female, Glial Fibrillary Acidic Protein/analysis/genetics, Glycogen Synthase Kinase 3/genetics/*metabolism, Humans, Male, Microtubule-Associated Proteins/analysis/genetics, Phosphopyruvate Hydratase/analysis/genetics, RNA; Messenger/analysis/biosynthesis, Reverse Transcriptase Polymerase Chain Reaction/methods, Sex Characteristics
IdentifiersURN: urn:nbn:se:uu:diva-72470PubMedID: 12941471OAI: oai:DiVA.org:uu-72470DiVA: diva2:100381