uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
Show others and affiliations
2003 (English)In: American Journal of Human Genetics, ISSN 0002-9297, Am J Hum Genet, ISSN 0002-9297, Vol. 73, no 1, 34-48 p.Article in journal (Refereed) Published
Abstract [en]

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.

Place, publisher, year, edition, pages
2003. Vol. 73, no 1, 34-48 p.
Keyword [en]
Bipolar Disorder/*genetics, Genome; Human, Genotype, Humans, Research Support; Non-U.S. Gov't, Research Support; U.S. Gov't; Non-P.H.S., Research Support; U.S. Gov't; P.H.S., Schizophrenia/*genetics
National Category
Neurosciences Genetics
URN: urn:nbn:se:uu:diva-72473PubMedID: 12802786OAI: oai:DiVA.org:uu-72473DiVA: diva2:100384
Available from: 2005-05-24 Created: 2005-05-24Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Jazin, Elena
By organisation
Evolutionary Biology
In the same journal
American Journal of Human Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link