uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders
Show others and affiliations
2002 (English)In: American Journal of Medical Genetics, ISSN 0148-7299, Vol. 114, no 2, 177-85 p.Article in journal (Refereed) Published
Abstract [en]

Convincing evidence for a genetic component in the etiology of affective disorders (AD), including bipolar affective disorder (BPAD) and unipolar affective disorder (UPAD), is supported by traditional and molecular genetic studies. Most arguments lead to the complex inheritance hypothesis, suggesting that the mode of inheritance is probably not Mendelian but most likely oligogenic (or polygenic) and that the contribution of genes could be moderate or weak. The purpose of the present European multicenter study (13 centers) was to test the potential role in BPAD and UPAD of two candidate dopaminergic markers, DRD2 and DRD3, using a case-control association design. The following samples were analyzed for DRD2: 358 BPAD/358 control (C) and 133 UPAD/ 133 C subjects, and for DRD3: 325 BPAD/ 325 C and 136 UPAD/136 C subjects. Patients and controls were individually matched for sex, age ( plus minus five years) and geographical origin. Evidence for significant association between BPAD and DRD2 emerged, with an over-representation of genotype 5-5 (P=0.004) and allele 5 (P=0.002) in BPAD cases compared to controls. No association was found for DRD2 in UPAD, and for DRD3 neither in BPAD or UPAD. Our results suggest that the DRD2 microsatellite may be in linkage disequilibrium with a nearby genetic variant involved in the susceptibility to BPAD. Our large European sample allowed for replicating of some previous reported positive findings obtained in other study populations.

Place, publisher, year, edition, pages
2002. Vol. 114, no 2, 177-85 p.
Keyword [en]
Alleles, Bipolar Disorder/*genetics, DNA/genetics, Europe, Female, Gene Frequency, Genotype, Humans, Male, Microsatellite Repeats, Odds Ratio, Polymorphism; Genetic, Receptors; Dopamine D2/*genetics
National Category
Neurosciences Genetics
URN: urn:nbn:se:uu:diva-72477DOI: 10.1002/ajmg.10118PubMedID: 11857579OAI: oai:DiVA.org:uu-72477DiVA: diva2:100388
Available from: 2005-05-24 Created: 2005-05-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11857579&dopt=Citation

Search in DiVA

By author/editor
Jazin, Elena
By organisation
Evolutionary Biology
In the same journal
American Journal of Medical Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 175 hits
ReferencesLink to record
Permanent link

Direct link