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Fixation biases affecting human SNPs?
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Evolutionary Biology. (Molecular Evolution)
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Evolutionary Biology.
2004 (English)In: Trends in Genetics, ISSN 0168-9525, Vol. 20, no 3, 122-126 p.Article in journal (Refereed) Published
Abstract [en]

Under neutrality all classes of mutation have an equal probability of becoming fixed in a population. In this article, we describe our analysis of the frequency distributions of >5000 human SNPs and provide evident of biases in the process of fixation of certain classes of point mutation that are most likely to be attributable to biased gene conversion. The results indicate an increased fixation probability of mutations that result in the incorporation of a GC base pair. Furthermore, in transcribed regions this process exhibits strand asymmetry, and is biased towards preserving a G base on the coding strand. Biased gene conversion has the potential to explain both existence of isochores and the compositional asymmetry in mammalian transcribed regions.

Place, publisher, year, edition, pages
2004. Vol. 20, no 3, 122-126 p.
National Category
Biochemistry and Molecular Biology Genetics
Identifiers
URN: urn:nbn:se:uu:diva-72594DOI: 10.1016/j.tig.2004.01.005PubMedID: 15049304OAI: oai:DiVA.org:uu-72594DiVA: diva2:100505
Available from: 2005-05-25 Created: 2005-05-25 Last updated: 2014-01-23Bibliographically approved

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Publisher's full textPubMedhttp://www.sciencedirect.com/science/article/pii/S0168952504000204

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Webster, Matthew Thomas

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