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Effects of ions and detergents in drug partition chromatography on liposomes
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry. Department of Physical Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Biochemistry.
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2004 (English)In: Journal of chromatography A, Vol. 1030, 273-278 p.Article in journal (Refereed) Published
Abstract [en]

We have determined drug partitioning into phospholipid bilayers by immobilized-liposome chromatography. Electrostatic effects on the drug partitioning were observed on neutral bilayers at low ionic strength. The size of the counterions affected the partitioning. When liposomes were supplemented with ionic detergents the partitioning of charged drugs was strongly affected, allowing complete separation of drugs of different charges which showed similar retention on neutral bilayers. Partial separation was obtained on bilayers containing fatty acid. Detergent ions or fatty acid inserted into phospholipid bilayers affected the partitioning of drugs much more than did free ions or phospholipid head group charges.

Place, publisher, year, edition, pages
2004. Vol. 1030, 273-278 p.
Keyword [en]
Liposomes, drug partitioning, immobilized-liposome chromatography, electrostatic effects, ionic strength, phospholipid bilayers, surfactants, drugs
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-72726DOI: doi:10.1016/j.chroma.2003.11.060OAI: oai:DiVA.org:uu-72726DiVA: diva2:100637
Available from: 2005-05-27 Created: 2005-05-27 Last updated: 2011-01-12

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Boija, ElisabetLundquist, AnnaEngvall, Caroline

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