Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
2005 (English)In: Journal of Clinical Investigation, ISSN 0021-9738, E-ISSN 1558-8238, Vol. 115, no 1, 118-127 p.Article in journal (Refereed) Published
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Place, publisher, year, edition, pages
2005. Vol. 115, no 1, 118-127 p.
Animals, Cell Differentiation/drug effects, Cell Movement/drug effects, Cells; Cultured, Coronary Vessels/cytology/drug effects, Endothelial Cells/*cytology/*drug effects, Hindlimb/blood supply/drug effects, Humans, Ischemia/chemically induced/*drug therapy/metabolism/*pathology, Mice, Microcirculation/drug effects, Myocardium/metabolism/pathology, Neovascularization; Physiologic/*drug effects, Phosphotyrosine/metabolism, Platelet-Derived Growth Factor/*pharmacology, Receptors; Platelet-Derived Growth Factor/metabolism, Research Support; Non-U.S. Gov't, Signal Transduction, Stem Cells/cytology/*drug effects
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-72730DOI: 10.1172/JCI19189PubMedID: 15630451OAI: oai:DiVA.org:uu-72730DiVA: diva2:100641