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Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)ORCID iD: 0000-0003-2256-6972
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
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2004 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 25, no 24, 2220-2225 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: There is limited data on echocardiographic and Doppler indices of cardiac function as predictors for congestive heart failure (CHF) in the general population. Myocardial performance index (MPI, also denoted TEI-Doppler index) reflects both left ventricular (LV) systolic and diastolic function.

METHODS AND RESULTS: We compared eight different echocardiographic and Doppler indices of cardiac function as predictors of CHF using a population-based cohort of 552 seventy-year-old men without CHF and significant valve disease at baseline (median follow-up time 8.2 years). In a stepwise multivariable Cox proportional-hazard analysis including the different indices of cardiac function, high MPI (above the 90th percentile of MPI [> or =0.91]), abnormal LV wall motion score index and a pseudo-normalized/restrictive E/A-ratio pattern independently predicted future CHF morbidity. After adding traditional CHF risk factors (age, previous myocardial infarction, hypertension, diabetes mellitus, hyperlipidaemia, smoking, LV hypertrophy and body mass index) to the above model, only a high MPI remained a significant predictor (hazard ratio 4.72, 95% CI 1.75-12.76, p=0.002).

CONCLUSION: MPI provides important prognostic information for the risk of future CHF, beyond other measurements of cardiac function and traditional heart failure risk factors in elderly men. MPI seems to be a clinically relevant indicator of cardiac function and may prove to be a valuable tool in assessing the risk of future CHF.

Place, publisher, year, edition, pages
2004. Vol. 25, no 24, 2220-2225 p.
Keyword [en]
Aged, Cohort Studies, Diabetic Angiopathies/etiology/physiopathology/ultrasonography, Echocardiography; Doppler/*methods, Follow-Up Studies, Heart Failure; Congestive/*etiology/physiopathology/prevention & control, Humans, Hyperlipidemia/complications/physiopathology, Hypertension/complications/physiopathology, Male, Prognosis, Research Support; Non-U.S. Gov't, Risk Factors, Smoking/adverse effects, Ventricular Dysfunction; Left/physiopathology/*ultrasonography
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-72760DOI: 10.1016/j.ehj.2004.10.021PubMedID: 15589639OAI: oai:DiVA.org:uu-72760DiVA: diva2:100671
Available from: 2005-09-14 Created: 2005-09-14 Last updated: 2016-01-25Bibliographically approved

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Ärnlöv, JohanIngelsson, ErikRisérus, UlfAndrén, BertilLind, Lars

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Ärnlöv, JohanIngelsson, ErikRisérus, UlfAndrén, BertilLind, Lars
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