High in-plane resolution T2-weighted magnetic resonance imaging of acute myocardial ischemia in pigs using the intravascular contrast agent NC100150 injection.
2004 (English)In: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 39, no 8, 470-478 p.Article in journal (Refereed) Published
Rationale and Objectives: The intravascular contrast agent NC100150 injection was tested for its ability to demarcate nonperfused myocardium in a porcine model of coronary occlusion.
Materials and Methods: A T2-weighted fast spin echo sequence was acquired ex vivo and in vivo during first pass and steady-state circulation of the contrast agent in 2 dosages (2 and 5 mg Fe/kg bw) or saline.
Results: Ex vivo, in the high-dose group, the volume of nonperfused myocardium determined from T2-weighted images was 99% of that determined from photographs where perfused myocardium stained with fluorescein. A significantly higher contrast to noise ratio between perfused and nonperfused myocardium was found (both ex and in vivo in steady state) compared with the control group. During first pass, a significant reduction in signal intensity (74 ± 18%) was found in perfused myocardium after contrast injection.
Conclusion: NC100150 injection, combined with T2-weighted turbo spin echo imaging, allowed detailed visualization of non-perfused myocardium in the steady state, which corresponded to the area at risk as determined by fluorescein.
Place, publisher, year, edition, pages
2004. Vol. 39, no 8, 470-478 p.
Animals, Contrast Media/administration & dosage, Coronary Circulation, In Vitro, Injections; Intravenous, Iron/administration & dosage/*diagnostic use, Magnetic Resonance Imaging/methods, Myocardial Infarction/*diagnosis/pathology, Myocardium/pathology, Oxides/administration & dosage/*diagnostic use, Research Support; Non-U.S. Gov't, Swine
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-72804PubMedID: 15257208OAI: oai:DiVA.org:uu-72804DiVA: diva2:100715