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High in-plane resolution T2-weighted magnetic resonance imaging of acute myocardial ischemia in pigs using the intravascular contrast agent NC100150 injection.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
2004 (English)In: Investigative Radiology, ISSN 0020-9996, E-ISSN 1536-0210, Vol. 39, no 8, 470-478 p.Article in journal (Refereed) Published
Abstract [en]

Rationale and Objectives: The intravascular contrast agent NC100150 injection was tested for its ability to demarcate nonperfused myocardium in a porcine model of coronary occlusion.

Materials and Methods: A T2-weighted fast spin echo sequence was acquired ex vivo and in vivo during first pass and steady-state circulation of the contrast agent in 2 dosages (2 and 5 mg Fe/kg bw) or saline.

Results: Ex vivo, in the high-dose group, the volume of nonperfused myocardium determined from T2-weighted images was 99% of that determined from photographs where perfused myocardium stained with fluorescein. A significantly higher contrast to noise ratio between perfused and nonperfused myocardium was found (both ex and in vivo in steady state) compared with the control group. During first pass, a significant reduction in signal intensity (74 ± 18%) was found in perfused myocardium after contrast injection.

Conclusion: NC100150 injection, combined with T2-weighted turbo spin echo imaging, allowed detailed visualization of non-perfused myocardium in the steady state, which corresponded to the area at risk as determined by fluorescein.

Place, publisher, year, edition, pages
2004. Vol. 39, no 8, 470-478 p.
Keyword [en]
Animals, Contrast Media/administration & dosage, Coronary Circulation, In Vitro, Injections; Intravenous, Iron/administration & dosage/*diagnostic use, Magnetic Resonance Imaging/methods, Myocardial Infarction/*diagnosis/pathology, Myocardium/pathology, Oxides/administration & dosage/*diagnostic use, Research Support; Non-U.S. Gov't, Swine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-72804PubMedID: 15257208OAI: oai:DiVA.org:uu-72804DiVA: diva2:100715
Available from: 2005-09-26 Created: 2005-09-26 Last updated: 2017-12-14Bibliographically approved

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Bjerner, TomasWikström, GerhardJohansson, LarsAhlström, Håkan

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