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Radionuklidterapi - möjlig väg mot bättre behandling av cancer: Hindret är bristen på kommersiellt tillgängliga nuklider i kliniken
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (Biomedicinsk strålningsvetenskap)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (Biomedicinsk strålningsvetenskap)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (Biomedicinsk strålningsvetenskap)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (Biomedicinsk strålningsvetenskap)
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2004 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 101, no 11, 1000-1006 p.Article in journal (Refereed) Published
Abstract [en]

About one third of all cancer develops into a spread disease that is difficult to treat. Radioimmunotherapy has during the last years proven to be of help when other therapy modalities fail in e.g. lymphomas. The development in this area is fast mainly due to substantial improvements in molecular biology and in our increasing understanding of specific receptor expressions in cancer cells. However, radionuclides used today, 131I and 90Y, are not optimal in that sense that they emit radiation mainly suitable to treat the bulk tumor and not the single cell and micrometastases present in spread disease. The article stresses the importance that radionuclides with more suitable emission of particles like 177Lu and 211At are made available for clinical research and routine.

Place, publisher, year, edition, pages
2004. Vol. 101, no 11, 1000-1006 p.
Keyword [en]
Humans, Iodine Radioisotopes/therapeutic use, Neoplasms/*radiotherapy, Radioisotopes/economics/pharmacokinetics/supply & distribution/*therapeutic use, Yttrium Radioisotopes/therapeutic use
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-72885PubMedID: 15055121OAI: oai:DiVA.org:uu-72885DiVA: diva2:100796
Available from: 2005-09-26 Created: 2005-09-26 Last updated: 2010-09-10Bibliographically approved

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Lundqvist, HansCarlsson, JörgenGedda, LarsTolmachev, Vladimir

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