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Trace element changes in sclerotic heart valves from patients undergoing aortic valve surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
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2002 (English)In: Biological Trace Element Research, ISSN 0163-4984, E-ISSN 1559-0720, Vol. 88, no 1, 9-24 p.Article in journal (Other academic) Published
Abstract [en]

Several trace elements are essential nutrients for an optimal functioning of organs and tissues, including the immune system and the heart. The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. The etiology of nonrheumatic aortic valve sclerosis is unknown, however. A prospective study was performed on trace element changes in the sclerotic valves of 46 patients undergoing surgical aortic valve replacement because of aortic stenosis. Valves from 15 individual forensic cases without known cardiac disease served as controls. The contents of 15 trace elements (Al, As, Cd, Ca, Co, Cu, Fe, Pb, Mg, Mn, Hg, Se, Ag, V, and Zn) were measured by inductively coupled plasma - mass spectrometry (ICP-MS) of aortic valve tissue from both patients and forensic autopsy controls. Some trace elements showed similar concentrations in sclerotic and control valves (Al, Ag, Hg, Mn), whereas a few were moderately changed in the sclerotic as compared with the control valves, including an increase in Cd by 52% (p < 0.05) and decreases in Se by 14% (p < 0.05), in V by 42% (p < 0,001), and in Cu by 45% (p < 0.001). However, there were pronounced increases (p < 0.001) in the concentrations of As (5-fold), Ca (70-fold), Co(10-fold), Fe (20-fold), Pb (8-fold), Mg (20-fold), and Zn (10-fold) in the sclerotic valves. Thus, sclerotic aortic valve disease is associated with a pronounced imbalance in several trace elements of well-known importance for cardiovascular and immune function as well as in trace elements with hitherto unknown significance.

Place, publisher, year, edition, pages
2002. Vol. 88, no 1, 9-24 p.
Keyword [en]
Adolescent, Adult, Aged, Aged; 80 and over, Aortic Valve/metabolism/*surgery, Arteriosclerosis/*metabolism, Case-Control Studies, Female, Humans, Male, Middle Aged, Research Support; Non-U.S. Gov't, Trace Elements/*metabolism
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-72915DOI: 10.1385/BTER:88:1:09PubMedID: 12117269OAI: oai:DiVA.org:uu-72915DiVA: diva2:100826
Available from: 2006-05-19 Created: 2006-05-19 Last updated: 2010-11-11Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12117269&dopt=Citation

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Nyström-Rosander, ChristinaThelin, StefanLindquist, OlleFriman, GöranIlbäck, Nils-Gunnar
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Department of Medical SciencesDepartment of Oncology, Radiology and Clinical ImmunologyDepartment of Surgical Sciences
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Biological Trace Element Research
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