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Penetration of fusidic acid and rifampicin into cerebrospinal fluid in low-grade inflammatory meningitis caused by Staphylococcus epidermidis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Friman)
2004 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 10, no 8, 765-768 p.Article in journal (Other academic) Published
Abstract [en]

Cerebrospinal fluid (CSF) concentration-time curves of rifampicin and fusidic acid were studied in a patient with post-operative meningitis caused by Staphylococcus epidermidis. The patient was treated with this combination of antimicrobial agents because of a severe hypersensitivity reaction to vancomycin. Peak CSF concentrations of rifampicin exceeded the MIC by > 60-fold, while those of fusidic acid just reached the MIC. CSF concentrations of fusidic acid were relatively stable within the range reported for patients with uninflamed meninges, but serum levels were surprisingly low. An increase in the metabolism of fusidic acid induced by rifampicin cannot be excluded.

Place, publisher, year, edition, pages
2004. Vol. 10, no 8, 765-768 p.
Keyword [en]
Anti-Bacterial Agents/blood/*cerebrospinal fluid/therapeutic use, Cerebrospinal Fluid/chemistry, Fusidic Acid/blood/*cerebrospinal fluid/therapeutic use, Humans, Inflammation/*drug therapy/microbiology, Male, Meningitis; Bacterial/*drug therapy/microbiology, Middle Aged, Rifampin/blood/*cerebrospinal fluid/therapeutic use, Staphylococcal Infections/drug therapy/microbiology, Staphylococcus epidermidis/*drug effects
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-72927DOI: 10.1111/j.1469-0691.2004.00953.xPubMedID: 15301684OAI: oai:DiVA.org:uu-72927DiVA: diva2:100838
Available from: 2005-09-20 Created: 2005-09-20 Last updated: 2010-12-09Bibliographically approved

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Sjölin, Jan

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