Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1.
2004 (English)In: Cell Signal, ISSN 0898-6568, Vol. 16, no 4, 515-20 p.Article in journal (Other scientific) Published
Binding of fibroblast growth factor (FGF) to the high affinity receptor-1 (FGFR-1) leads to activation of its endogenous tyrosine kinase activity. A number of substrates for the FGFR-1 kinase have been identified. Among those, FGF receptor-substrate-2 (FRS-2) was identified by virtue of its interaction with p13suc, a yeast protein involved in cell cycle regulation. We have used immobilized p13suc to identify a new substrate for FGRF-1, which is identical to "translocated in liposarcoma" (TLS). TLS is a RNA/DNA-binding protein which occurs in fusion products with different transcription factors in a variety of solid tumours. We show that TLS is tyrosine phosphorylated in intact cells by a number of different growth factors, indicating a role in growth regulation.
Place, publisher, year, edition, pages
2004. Vol. 16, no 4, 515-20 p.
Animals, Cell Fractionation, Fibroblast Growth Factors/*metabolism, Liposarcoma/*metabolism, Membrane Proteins/*metabolism, Mice, Phosphoproteins/*metabolism, Phosphorylation, Receptor Protein-Tyrosine Kinases/*metabolism, Receptors; Fibroblast Growth Factor/*metabolism, Research Support; Non-U.S. Gov't, Research Support; U.S. Gov't; P.H.S., Swiss 3T3 Cells, Tyrosine/metabolism
IdentifiersURN: urn:nbn:se:uu:diva-72992PubMedID: 14709340OAI: oai:DiVA.org:uu-72992DiVA: diva2:100903