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Guidelines for prevention and treatment of adverse effects of antipsychotic drugs on glucose-insulin homeostasis and lipid metabolism
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Pharmacogenetics)
2004 (English)In: Psychopharmacology, ISSN 0033-3158, Vol. 175, no 1, 1-6 p.Article in journal (Refereed) Published
Abstract [en]

RATIONALE: With the antipsychotic drugs available today, especially with some of the newer, atypical antipsychotics, metabolic side effects, such as weight gain, diabetes mellitus and lipid abnormalities, have become a complication to the drug therapy that have to be recognized and treated. OBJECTIVE: The aim of this article is to suggest guidelines for prevention and treatment of adverse effects of antipsychotics on glucose-insulin homeostasis and lipid metabolism, whereas strategies for management of antipsychotic-induced weight gain are summarized elsewhere. METHOD: The guidelines are based on results of experimental and clinical studies presented in the article, as well as on a recently published review of 180 articles in the field. RESULTS: Both conventional and atypical antipsychotics can indirectly, by causing obesity, promote development of insulin resistance and type-2 diabetes. In addition, some atypical agents probably directly induce hyperinsulinemia, followed by weight gain, insulin resistance and drug-induced, sometimes insulin-dependent, diabetes. CONCLUSION: In this article, guidelines for the management of adverse metabolic effects of antipsychotics are described.

Place, publisher, year, edition, pages
2004. Vol. 175, no 1, 1-6 p.
Keyword [en]
Antipsychotic Agents/*adverse effects, Clinical Trials, Glucose/*metabolism, Glucose Metabolism Disorders/chemically induced/*prevention & control, Homeostasis/*drug effects, Humans, Insulin/*metabolism, Lipids/*metabolism, Practice Guidelines
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73039DOI: 10.1007/s00213-004-1922-7PubMedID: 15221198OAI: oai:DiVA.org:uu-73039DiVA: diva2:100950
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2009-06-12Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15221198&dopt=Citation

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Dahl, Marja-Liisa
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