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Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2004 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 31, no 7, 867-874 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to investigate the potential use of PET in vivo to record cytotoxic effects of 2-methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol. The anti-proliferative and pro-apoptotic effects of 2-ME on human prostate cancer cell (PC3) aggregates in vitro, were correlated with the uptake of fluoro-deoxy-D-glucose, FMAU and choline labelled with 18F, 11C, or 3H. 2-ME clearly reduced growth of PC3 aggregates and induced apoptosis in a dose-dependent manner. However, the uptake of the putative proliferation markers 11C-FMAU or 3H-choline failed to record the growth inhibitory effects of 2-ME on PC3 cell aggregates. The uptake of 18F-FDG was used as a marker for effects on cellular metabolism and also failed to show any dose-dependent effects in PC3 aggregates. The use of these PET-tracers in vivo is therefore not recommended in order to evaluate the cytotoxic effects of 2-ME on human prostate cancer cells.

Place, publisher, year, edition, pages
2004. Vol. 31, no 7, 867-874 p.
Keyword [en]
Antineoplastic Agents/administration & dosage, Apoptosis/*drug effects, Cell Aggregation/drug effects, Cell Line; Tumor, Cell Proliferation/*drug effects, Comparative Study, Dose-Response Relationship; Drug, Estradiol/*administration & dosage/*analogs & derivatives, Humans, Male, Neoplasm Staging/methods, Positron-Emission Tomography/*methods, Prostatic Neoplasms/drug therapy/*metabolism/pathology/*radionuclide imaging, Radioisotopes/*diagnostic use/*pharmacokinetics, Radiopharmaceuticals/diagnostic use/pharmacokinetics, Reproducibility of Results, Research Support; Non-U.S. Gov't, Sensitivity and Specificity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73054DOI: 10.1016/j.nucmedbio.2004.03.015PubMedID: 15464388OAI: oai:DiVA.org:uu-73054DiVA: diva2:100965
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2017-12-14Bibliographically approved

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Davoodpour, PadidehBergström, MatsLandström, Maréne

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