uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Integration of signalling pathways regulated by small GTPases and calcium
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2004 (English)In: Biochimica et Biophysica Acta, ISSN 0006-3002, Vol. 1742, no 1-3, 51-58 p.Article, review/survey (Refereed) Published
Abstract [en]

The Ras superfamily of small GTPases constitutes a large group of structurally and functionally related proteins. They function as signalling switches in numerous signalling cascades in the cell. During the recent years, an increased awareness of a communication between signalling systems employing Ras-like GTPases and signalling systems employing calcium has emerged. For instance, the intensity of the activation of Ras-like GTPases is regulated by calcium-dependent mechanisms, acting on proteins that facilitate the activation or inactivation of the small GTPases. Other Ras-like GTPases have a direct influence on calcium signalling by regulating the activity of certain calcium channels. In addition, several small GTPases collaborate with calcium signalling in regulating cellular processes, such as cell adhesion, cell migration and exocytosis.

Place, publisher, year, edition, pages
2004. Vol. 1742, no 1-3, 51-58 p.
Keyword [en]
Animals, Calcium/*physiology, GTP Phosphohydrolases/*physiology, Homeostasis, Humans, Research Support; Non-U.S. Gov't, Signal Transduction/*physiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73063DOI: 10.1016/j.bbamcr.2004.09.029PubMedID: 15590055OAI: oai:DiVA.org:uu-73063DiVA: diva2:100974
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2013-10-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15590055&dopt=Citation

Search in DiVA

By author/editor
Aspenström, Pontus
By organisation
Ludwig Institute for Cancer Research
In the same journal
Biochimica et Biophysica Acta
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 182 hits
ReferencesLink to record
Permanent link

Direct link