uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
PET in the diagnosis of neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Sundin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology. (Öberg)
Uppsala University Petcentre (Imanet).
Uppsala University Petcentre (Imanet).
Show others and affiliations
2004 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1014, 246-257 p.Article in journal (Refereed) Published
Abstract [en]

For general oncological imaging, positron emission tomography (PET) using [18F]fluoro-deoxy-glucose (FDG) has evolved as a powerful functional imaging modality. Unfortunately, FDG-PET has not been as advantageous for imaging gastropancreatic neuroendocrine tumors, and only tumors with high proliferative activity and low differentiation have shown an increased FDG uptake. Therefore, the 11C-labeled amine precursors L-dihydroxyphenylalanine and 5-hydroxy-L-tryptophan (5-HTP) were developed for PET imaging of these tumors. Because of the higher tumor uptake of the latter tracer in a study of patients with endocrine pancreatic tumors, 11C-5-HTP was chosen for further evaluation. In comparative studies of patients with carcinoids and endocrine pancreatic tumors, 5-HTP-PET proved better than CT and somatostatin receptor scintigraphy for tumor visualization, and many small, previously overlooked lesions were diagnosed by 11C-5-HTP-PET. The strong correlation found during medical treatment between the changes in the transport rate constant at repeated PET and those of U-HIAA indicates the possible use of 11C-5-HTP-PET also for therapy monitoring. By premedication of patients with Carbidopa orally before PET examination, in order to block the aromatic amino acid decarboxylase enzyme, the decarboxylation rate of 11C-5-HTP was decreased, leading to a higher tumor uptake and a considerably lower urinary radioactivity concentration.

Place, publisher, year, edition, pages
2004. Vol. 1014, 246-257 p.
Keyword [en]
Carcinoid Tumor/*radionuclide imaging, Humans, Neuroendocrine Tumors/*radionuclide imaging, Pancreatic Neoplasms/*radionuclide imaging, Tomography; Emission-Computed/*methods
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-73083DOI: 10.1196/annals.1294.027PubMedID: 15153441OAI: oai:DiVA.org:uu-73083DiVA: diva2:100994
Available from: 2005-09-20 Created: 2005-09-20 Last updated: 2014-09-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15153441&dopt=Citation

Search in DiVA

By author/editor
Sundin, AndersEriksson, BarbroLångström, BengtÖberg, KjellÖrlefors, Håkan
By organisation
RadiologyEndocrine Oncology
In the same journal
Annals of the New York Academy of Sciences
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 202 hits
ReferencesLink to record
Permanent link

Direct link