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An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2001 (English)In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 172, no 2, 107-113 p.Article in journal (Refereed) Published
Abstract [en]

This study was designed to evaluate the effects of an ordinary mixed meal on endothelium-dependent vasodilation. Ten young healthy volunteers were given a mixed meal (minced meat sauce with rice, 900 kcal, 34% of the energy content was fat). In the fasting state, at 60 and 120 min after the start of the meal, endothelium-dependent vasodilation and endothelium-independent vasodilation were evaluated by local infusion of metacholine (4 microg min (-1)) and sodium nitroprusside (10 microg min (-1)) in the brachial artery. Blood flow in the forearm was measured using venous occlusion plethysmography. Endothelium-dependent vasodilation decreased from 15.4 +/- 3.3 (mean +/- SD) at fasting to 13.7 +/- 3.5 mL min (-1) (100 mL tissue)-1 (P < 0.01) 60 min after feeding, but had returned to the fasting level at 120 min. At 60 min, but not in the fasting state, the serum level of free fatty acids was inversely related to endothelium-dependent vasodilation (r=-0.74, P < 0.05), although no significant net changes in FFA levels were seen. Endothelium-independent vasodilation was not affected by the mixed meal. No similar attenuations in endothelium-dependent vasodilation were seen during control meals. In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function.

Place, publisher, year, edition, pages
2001. Vol. 172, no 2, 107-113 p.
Keyword [en]
Adult, Blood Flow Velocity/drug effects, Chemistry; Clinical, Choline/pharmacology, Eating/*physiology, Endothelium; Vascular/drug effects/physiology, Fasting/physiology/psychology, Fatty Acids; Nonesterified/blood, Female, Food, Food Deprivation/physiology, Forearm/blood supply, Humans, Male, Nitroprusside/pharmacology, Plethysmography, Triglycerides/blood, Vasodilation/drug effects/*physiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73100DOI: 10.1046/j.1365-201X.2001.00845.xPubMedID: 11442450OAI: oai:DiVA.org:uu-73100DiVA: diva2:101011
Available from: 2008-06-11 Created: 2008-06-11 Last updated: 2010-08-11Bibliographically approved

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Karlström, BritaBerne, ChristianLind, Lars

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