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Early response of breast cancer bone metastases to chemotherapy evaluated with MR imaging
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
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2001 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 42, no 2, 198-206 p.Article in journal (Other academic) Published
Abstract [en]

PURPOSE:

To compare T1-weighted spin-echo and fat-suppressed long echo time inversion recovery turbo spin-echo (long TE IR-TSE) MR images in the evaluation of early response of breast cancer bone metastases to chemotherapy.

MATERIAL AND METHODS:

Eighteen breast cancer patients with known bone metastases were investigated prospectively by MR, using T1-weighted and long TE IR-TSE sequences on the sternum, spine, pelvis and proximal femora, before and after a median of 6 courses of chemotherapy. Therapeutic response evaluation with MR was based on change in tumor size assessed quantitatively by measuring all focal metastases, and change in pattern and signal intensity (SI) of the metastases, assessed visually. Combined response evaluation based on clinical findings, conventional radiography, and scintigraphy was used as reference.

RESULTS:

Progressive disease (2 patients) and no change (4 patients) were assessed equally well on both MR sequences. Long TE IR-TSE demonstrated partial response with higher accuracy than T1-weighted images, 58% (7/12 patients) vs. 17% (2/12 patients). In patients without progression there was an SI increase in or around the metastases in 6 patients on T1-weighted images and in 7 patients on long TE IR-TSE images.

CONCLUSION:

The long TE IR-TSE sequence demonstrated early partial response of breast cancer bone metastases to chemotherapy more accurately than the T1-weighted sequence.

Place, publisher, year, edition, pages
2001. Vol. 42, no 2, 198-206 p.
Keyword [en]
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Bone Neoplasms/diagnosis/*drug therapy/*secretion, Breast Neoplasms/*pathology, Comparative Study, Female, Humans, Magnetic Resonance Imaging/methods, Middle Aged, Research Support; Non-U.S. Gov't, Spinal Neoplasms/diagnosis/drug therapy/secretion
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73107PubMedID: 11259949OAI: oai:DiVA.org:uu-73107DiVA: diva2:101018
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2017-12-14Bibliographically approved

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Lindman, HenrikAhlström, Håkan

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