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Assessment of T1 and T2* effects in vivo and ex vivo using iron oxide nanoparticles in steady state: dependence on blood volume and water exchange
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Radiologi. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Radiologi. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Ahlström)
2002 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 47, no 3, 461-471 p.Article in journal (Refereed) Published
Abstract [en]

Accurate knowledge of the relationship between contrast agent concentration and tissue relaxation is a critical requirement for quantitative assessment of tissue perfusion using contrast-enhanced MRI. In the present study, using a pig model, the relationship between steady-state blood concentration levels of an iron oxide nanoparticle with a hydrated diameter of 12 nm (NC100150 Injection) and changes in the transverse and longitudinal relaxation rates (1/T2* and 1/T1, respectively) in blood, muscle, and renal cortex was investigated at 1.5 T. Ex vivo measurements of 1/T2* and 1/T1 were additionally performed in whole pig blood spiked with different concentrations of the iron oxide nanoparticle. In renal cortex and muscle, 1/T2* increased linearly with contrast agent concentration with slopes of 101 +/-22 s(-1)mM(-1) and 6.5 +/-0.9 s(-1)mM(-1) (mean +/- SD), respectively. In blood, 1/T2* increased as a quadratic function of contrast agent concentration, with different quadratic terms in the ex vivo vs. the in vivo experiments. In vivo, 1/T1 in blood increased linearly with contrast agent concentration, with a slope (T1-relaxivity) of 13.9 +/- 0.9 s(-1)mM(-1). The achievable increase in 1/T1 in renal cortex and muscle was limited by the rate of water exchange between the intra- and extravascular compartments and the 1/T1-curves were well described by a two-compartment water exchange limited relaxation model.

Place, publisher, year, edition, pages
2002. Vol. 47, no 3, 461-471 p.
Keyword [en]
Animals, Blood Volume, Body Water/metabolism, Contrast Media/*pharmacokinetics, Image Processing; Computer-Assisted, Iron/*pharmacokinetics, Kidney Cortex/*anatomy & histology, Magnetic Resonance Imaging/*methods, Muscles/*anatomy & histology, Nanotechnology, Oxides/*pharmacokinetics, Particle Size, Research Support; Non-U.S. Gov't, Swine
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-73117DOI: 10.1002/mrm.10066PubMedID: 11870832OAI: oai:DiVA.org:uu-73117DiVA: diva2:101028
Available from: 2007-03-14 Created: 2007-03-14 Last updated: 2017-12-14Bibliographically approved

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Bjørnerud, AtleJohansson, Lars O.Ahlström, Håkan K.

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