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Treatment with irbesartan or atenolol improves endothelial function in essential hypertension
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
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2001 (English)In: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 19, no 10, 1813-1818 p.Article in journal (Other academic) Published
Abstract [en]

OBJECTIVES: To investigate if antihypertensive treatment could improve endothelium-dependent vasodilatation in hypertensive patients, and whether the angiotensin II subtype-1 (AT1)-receptor antagonist irbesartan and the beta1-receptor antagonist atenolol would differ in this respect. SUBJECTS AND METHODS: Thirty-four patients (28 men and six women) with mild-to-moderate essential hypertension (diastolic blood pressure 90-120 mmHg) were randomized to once daily 150-300 mg irbesartan or 50-100 mg atenolol in a double-blind fashion, preceded by a placebo run-in period. Forearm blood flow (FBF) was assessed by venous occlusion plethysmography during local intra-arterial infusions of methacholine and sodium nitroprusside, to evaluate endothelium-dependent and endothelium-independent vasodilatation, respectively. Measurements of FBF were undertaken at the end of the run-in placebo period and repeated after 3 months of active antihypertensive treatment. RESULTS: Irbesartan and atenolol induced a similar decline in blood pressure (from 171/107 to 158/98 mmHg, P < 0.05), and improved endothelium-dependent vasodilatation (e.g. an increase in FBF response to 4 microg/min methacholine from 325 +/- 29% to 411 +/- 41%, P < 0.05), with no difference between the two study drugs. No significant changes in endothelium-independent vasodilatation were induced by irbesartan or by atenolol. CONCLUSIONS: The present study shows that 3 months of antihypertensive therapy with irbesartan or atenolol improves endothelium-dependent vasodilatation.

Place, publisher, year, edition, pages
2001. Vol. 19, no 10, 1813-1818 p.
Keyword [en]
Adrenergic beta-Antagonists/*therapeutic use, Antihypertensive Agents/*therapeutic use, Atenolol/*therapeutic use, Biphenyl Compounds/*therapeutic use, Double-Blind Method, Endothelium; Vascular/*drug effects/*physiopathology, Female, Forearm/blood supply, Humans, Hypertension/*drug therapy/*physiopathology, Male, Middle Aged, Receptor; Angiotensin; Type 1, Receptors; Angiotensin/antagonists & inhibitors, Regional Blood Flow/drug effects, Research Support; Non-U.S. Gov't, Tetrazoles/*therapeutic use, Vasodilation/drug effects
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73118PubMedID: 11593101OAI: oai:DiVA.org:uu-73118DiVA: diva2:101029
Available from: 2005-05-31 Created: 2005-05-31 Last updated: 2010-08-10Bibliographically approved

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Lind, Lars

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