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Toward a rational combinaTORial therapy for multiple myeloma
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
2004 (English)In: Blood, Vol. 104, no 13, 3845-3846 p.Article, book review (Other (popular scientific, debate etc.)) Published
Abstract [en]

The phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) signaling pathway regulates growth and survival in multiple myeloma (MM) in vitro. Of the many substrates regulating caspase activity and apoptosis downstream of Akt, the mammalian target of rapamycin, mTOR, has been thought to act as a special survival checkpoint kinase in several cell types. In 2 articles appearing in this issue of Blood, such a function has now been ascribed to mTOR also in MM cells in vivo.

Place, publisher, year, edition, pages
2004. Vol. 104, no 13, 3845-3846 p.
Keyword [en]
myeloma, rapamycin
Identifiers
URN: urn:nbn:se:uu:diva-73138OAI: oai:DiVA.org:uu-73138DiVA: diva2:101049
Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2011-01-12

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http://www.bloodjournal.org/cgi/content/full/104/13/3845

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Jernberg Wiklund, HelenaNilsson, Kenneth

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