PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
2000 (English)In: Nat Cell Biol, ISSN 1465-7392, Vol. 2, no 5, 302-9 p.Article in journal (Refereed) Published
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
Place, publisher, year, edition, pages
2000. Vol. 2, no 5, 302-9 p.
Animals, COS Cells, Endopeptidases/*metabolism, Epithelial Cells/chemistry/enzymology, Gene Expression/physiology, Gene Expression Regulation; Developmental, Humans, In Situ Hybridization, Insects, Kidney/chemistry/embryology/enzymology, Ligands, Mesoderm/chemistry/enzymology, Mice, Molecular Sequence Data, Myocardium/chemistry/enzymology, Platelet-Derived Growth Factor/chemistry/*genetics/*metabolism/pharmacology, Protein Structure; Tertiary, RNA; Messenger/analysis, Rabbits, Receptor; Platelet-Derived Growth Factor alpha/*metabolism, Research Support; Non-U.S. Gov't, Sequence Homology; Amino Acid, Transgenes/physiology
IdentifiersURN: urn:nbn:se:uu:diva-73151PubMedID: 10806482OAI: oai:DiVA.org:uu-73151DiVA: diva2:101062