uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Show others and affiliations
2000 (English)In: Nat Cell Biol, ISSN 1465-7392, Vol. 2, no 5, 302-9 p.Article in journal (Refereed) Published
Abstract [en]

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

Place, publisher, year, edition, pages
2000. Vol. 2, no 5, 302-9 p.
Keyword [en]
Animals, COS Cells, Endopeptidases/*metabolism, Epithelial Cells/chemistry/enzymology, Gene Expression/physiology, Gene Expression Regulation; Developmental, Humans, In Situ Hybridization, Insects, Kidney/chemistry/embryology/enzymology, Ligands, Mesoderm/chemistry/enzymology, Mice, Molecular Sequence Data, Myocardium/chemistry/enzymology, Platelet-Derived Growth Factor/chemistry/*genetics/*metabolism/pharmacology, Protein Structure; Tertiary, RNA; Messenger/analysis, Rabbits, Receptor; Platelet-Derived Growth Factor alpha/*metabolism, Research Support; Non-U.S. Gov't, Sequence Homology; Amino Acid, Transgenes/physiology
URN: urn:nbn:se:uu:diva-73151PubMedID: 10806482OAI: oai:DiVA.org:uu-73151DiVA: diva2:101062
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2011-01-14

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Bäckström, GudrunBoström, HansHeldin, Carl-Henrik
By organisation
Department of Genetics and Pathology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 193 hits
ReferencesLink to record
Permanent link

Direct link