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Endothelium-dependent vasodilation in normotensive subjects with a familial history of essential hypertension and in young subjects with borderline hypertension
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
2002 (English)In: Blood Pressure, ISSN 0803-7051, Vol. 11, no 5, 279-284 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function. METHODS: Fifteen young (26 +/- 4 years) healthy normotensive (115 +/- 8/71 +/- 6 mmHg) subjects with a FHH, 31 matched healthy normotensive subjects without FHH and seven BHT (143 +/- 12/92 +/- 2 mmHg), otherwise healthy, young males underwent evaluation of endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIDV), by means of local intra-arterial infusions of methacholine (MCh, evaluating EDV) and sodium nitroprusside (SNP, evaluating EIDV) in the forearm. Forearm blood flow (FBF) was measured by venous occlusion plethysmography. RESULTS: Although there was no significant difference between normotensive subjects with and without a FHH regarding FBF during vasodilation induced by MCh or SNP, the subjects with a FHH presented a significantly suppressed endothelial function index, calculated as the ratio between EDV and EIDV, when compared to subjects without FHH (1.04 +/- 0.15 vs. 1.24 +/- 0.23, p < 0.01). Also in the group of BHT subjects, the endothelial function index was suppressed (1.01 +/- 0.18, p < 0.01), in this case due to a significantly attenuated EDV (p < 0.05), when compared to male subjects without a FHH. CONCLUSION: The present findings suggest an early occurrence of endothelial dysfunction in the development of essential hypertension.

Place, publisher, year, edition, pages
2002. Vol. 11, no 5, 279-284 p.
Keyword [en]
Adult, Endothelium; Vascular/*physiopathology, Female, Forearm/blood supply, Humans, Hypertension/genetics/*physiopathology, Male, Medical Records, Methacholine Chloride/pharmacology, Nitroprusside/pharmacology, Plethysmography, Reference Values, Regional Blood Flow, Severity of Illness Index, Vasodilation, Vasodilator Agents/pharmacology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73218DOI: 10.1080/080370502320779485PubMedID: 12458650OAI: oai:DiVA.org:uu-73218DiVA: diva2:101129
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2010-08-10Bibliographically approved

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Lind, Lars

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