Platelet-derived growth factor is angiogenic in vivo
1992 (English)In: Growth Factors, ISSN 0897-7194, Vol. 7, no 4, 261-266 p.Article in journal (Other academic) Published
PDGF receptors have recently been found to be expressed in microvascular endothelium in vivo under circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membrane in vivo. PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells. In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.
Place, publisher, year, edition, pages
1992. Vol. 7, no 4, 261-266 p.
Allantois/blood supply, Animals, Brain/blood supply, Capillaries/cytology, Chemotaxis, Chick Embryo, Chorion/blood supply, Comparative Study, Endothelium; Vascular/cytology/physiology, Macromolecular Substances, Neovascularization; Pathologic, Platelet-Derived Growth Factor/chemistry/*pharmacology, Rats
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-73249PubMedID: 1284870OAI: oai:DiVA.org:uu-73249DiVA: diva2:101160