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Platelet-derived growth factor is angiogenic in vivo
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1992 (English)In: Growth Factors, ISSN 0897-7194, Vol. 7, no 4, 261-266 p.Article in journal (Other academic) Published
Abstract [en]

PDGF receptors have recently been found to be expressed in microvascular endothelium in vivo under circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membrane in vivo. PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells. In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.

Place, publisher, year, edition, pages
1992. Vol. 7, no 4, 261-266 p.
Keyword [en]
Allantois/blood supply, Animals, Brain/blood supply, Capillaries/cytology, Chemotaxis, Chick Embryo, Chorion/blood supply, Comparative Study, Endothelium; Vascular/cytology/physiology, Macromolecular Substances, Neovascularization; Pathologic, Platelet-Derived Growth Factor/chemistry/*pharmacology, Rats
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73249PubMedID: 1284870OAI: oai:DiVA.org:uu-73249DiVA: diva2:101160
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2013-03-18Bibliographically approved

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Smits, AnjaSiegbahn, Agneta

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