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Specific binding of B-CLL cell-derived chemokinetic inhibitory factor (CIF) to human polymorphonuclear leukocytes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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1987 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 39, no 2, 172-179 p.Article in journal (Refereed) Published
Abstract [en]

The chemokinetic inhibitory factor (CIF) is a recently described B-cell derived lymphokine that mediates a chemokinetic inhibitory effect on human polymorphonuclear leukocyte (PMN) migration. In the present report the interaction of CIF with the neutrophil plasma membrane was studied. Normal human peripheral blood neutrophils and purified neutrophil plasma membranes selectively removed biologic activity from CIF-containing concentrates obtained during the purification procedure from conditioned medium. Removal was obtained at both 4 degrees C and 37 degrees C. Furthermore, HL-60 cells treated with dimethyl sulfoxide removed CIF activity (granulocyte-like cells) but HL-60 cells treated with 12-O-tetradecanoylphorbol-13-acetate (macrophage-like cells) did not. Purified human blood monocytes, cells from the macrophage-like U-937 cell line and cells from the basophilic leukemia cell line KU-812 did not remove CIF. These studies suggest that neutrophils express specific binding sites for CIF-activity.

Place, publisher, year, edition, pages
1987. Vol. 39, no 2, 172-179 p.
Keyword [en]
Binding Sites, Cell Membrane/metabolism, Chemotactic Factors/antagonists & inhibitors, Glucosamine/pharmacology, Hexosamines/pharmacology, Humans, In Vitro, Lymphokines/*metabolism, Neutrophils/*metabolism, Research Support; Non-U.S. Gov't, Tumor Cells; Cultured
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-73256PubMedID: 3666104OAI: oai:DiVA.org:uu-73256DiVA: diva2:101167
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2010-11-23Bibliographically approved

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Siegbahn, Agneta

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