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Production of chemokinetic inhibitory factor (CIF) by normal blood and spleen B lymphocytes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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1986 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 10, no 2, 179-186 p.Article in journal (Other academic) Published
Abstract [en]

We have recently reported the partial purification and characterization of of a new lymphokine, the heat-labile chemokinetic inhibitory factor (CIF) which inhibits neutrophil movement. We have also shown that this lymphokine is produced and secreted by cultured B-chronic lymphocytic leukaemia (CLL) cells in vitro. The present study shows that highly purified resting normal B lymphocytes from blood and spleen have the capacity to produce CIF spontaneously. After activation with anti-IgM or EBV-infection the lymphocytes produced a number of other factors, heat-stable chemokinetic inhibitory factors and heat-labile chemokinetic enhancing factors. Supernatants from a collection of human B-cell lines representing different stages of B-cell differentiation were also investigated. None of these cell lines produced CIF. The present results show that the production of CIF is not restricted to the malignant B-CLL cell but is also produced by a subset of normal blood and spleen B cells.

Place, publisher, year, edition, pages
1986. Vol. 10, no 2, 179-186 p.
Keyword [en]
B-Lymphocytes/cytology/*immunology, Cell Line, Cell Separation, Cells; Cultured, Chemotactic Factors/antagonists & inhibitors, Humans, Leukemia; Lymphocytic, Lymphokines/*biosynthesis/blood, Lymphoma, Multiple Myeloma, Neutrophils/cytology, Research Support; Non-U.S. Gov't, Spleen/*immunology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73258PubMedID: 3485223OAI: oai:DiVA.org:uu-73258DiVA: diva2:101169
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2010-11-23Bibliographically approved

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Siegbahn, Agneta
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