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Identification of a chemokinetic inhibitor in serum from patients with chronic lymphocytic leukaemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
1982 (English)In: Scandinavian journal of haematology, ISSN 0036-553X, Vol. 28, no 2, 122-131 p.Article in journal (Refereed) Published
Abstract [en]

The effects of serum from patients with chronic lymphocytic leukaemia (CCL) on normal polymorphonuclear leucocyte migration (PMN) were examined by means of the leading front technique, using a modified Boyden chamber. 18 randomly selected patients were studied. 13 patients had a reduced chemokinetic activity. The defective migration was explained by the finding in serum from these patients of cell-directed inhibitory activity which was destroyed by heating (56 degrees C, 30 min). The B-lymphocytes as the origin of the inhibitory activity was suggested by the presence of a similar activity in supernatants from cultured tumour cells. 6 of the 18 patients had the combination of a defective chemokinetic activity and low levels of immunoglobulins. These 6 patients had an increased tendency towards infections.

Place, publisher, year, edition, pages
1982. Vol. 28, no 2, 122-131 p.
Keyword [en]
Aged, Aminopeptidases, B-Lymphocytes/immunology, Cell Migration Inhibition, Chemotactic Factors/*antagonists & inhibitors/immunology, Female, Humans, Immunoglobulins/analysis, Leukemia; Lymphocytic/*blood/immunology, Leukocyte Migration-Inhibitory Factors/immunology, Male, Middle Aged, Neutrophils/*immunology, Research Support; Non-U.S. Gov't
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73262PubMedID: 7046030OAI: oai:DiVA.org:uu-73262DiVA: diva2:101172
Available from: 2005-06-01 Created: 2005-06-01 Last updated: 2010-11-23Bibliographically approved

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Siegbahn, Agneta
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