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Blood flow is an important determinant of forearm glucose uptake following a mixed meal
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Geriatrics)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2003 (English)In: Acta Diabetologica, ISSN 0940-5429, E-ISSN 1432-5233, Vol. 40, no 3, 113-117 p.Article in journal (Refereed) Published
Abstract [en]

Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p<0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p<0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p<0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p<0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p<0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.

Place, publisher, year, edition, pages
2003. Vol. 40, no 3, 113-117 p.
Keyword [en]
Adult, Blood Glucose/*metabolism, Blood Pressure, Fatty Acids; Nonesterified/blood, Forearm/*blood supply, Glucose/*metabolism, Humans, Insulin/blood, Kinetics, Oxygen Consumption, Plethysmography, Postprandial Period, Reference Values, Regional Blood Flow/*physiology, Time Factors, Triglycerides/blood
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73285DOI: 10.1007/s00592-003-0098-7PubMedID: 14605966OAI: oai:DiVA.org:uu-73285DiVA: diva2:101195
Available from: 2007-03-12 Created: 2007-03-12 Last updated: 2010-08-11Bibliographically approved

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Berne, ChristianLind, Lars

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