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Activation of mitogen-activated protein kinases in experimental cerebral ischemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2002 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, Vol. 106, no 6, 333-40 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Mitogen-activated protein kinases (MAPK) regulate cell survival and differentiation. The aim of the present study is to investigate the activation pattern of different MAPKs [extracellular signal-regulated kinase (ERK), c-jun-N-terminal kinase (JNK) and p38] after cerebral ischemia. MATERIAL AND METHODS: Rats were subjected to cerebral ischemia using a model for transient (2 h) and permanent middle cerebral artery occlusion (MCAO). The rats were allowed 6 h to 1 week of survival before immunohistochemical evaluation with phospho-specific antibodies, recognizing activated MAPKs. RESULTS: ERK was activated in ipsilateral blood vessels, neurons and glia, but also in contralateral vessels. JNK activation was absent in neurons but appeared in arterial blood vessels and glia at the lesion side. Active p38 was observed in macrophages in maturing infarcts. CONCLUSIONS: ERK and JNK may participate in the angiogenic response to cerebral ischemia. ERK, but not JNK, was activated in neurons, possibly indicating a pathophysiologic role. Active p38 might be involved in the inflammatory reaction.

Place, publisher, year, edition, pages
2002. Vol. 106, no 6, 333-40 p.
Keyword [en]
Animals, Brain Ischemia/mortality/*pathology/*physiopathology, Cerebral Arteries/pathology, Cerebral Veins/pathology/physiopathology, Disease Models; Animal, Enzyme Activation/*physiology, JNK Mitogen-Activated Protein Kinases, Macrophages/pathology, Male, Mitogen-Activated Protein Kinases/analysis/*physiology, Neural Pathways/*physiology, Neuroglia/pathology, Neurons/pathology, Rats, Rats; Sprague-Dawley, Research Support; Non-U.S. Gov't, Survival Rate, p38 Mitogen-Activated Protein Kinases
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73326DOI: 10.1034/j.1600-0404.2002.01313.xPubMedID: 12460137OAI: oai:DiVA.org:uu-73326DiVA: diva2:101236
Available from: 2007-03-07 Created: 2007-03-07Bibliographically approved

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Lennmyr, FredrikGerwins, PärTerent, Andreas

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