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Interaction of host and viral risk factors for development of cervical carcinoma in situ
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology. (Cervix cancer)
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
2005 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 117, no 4, 690-692 p.Article in journal (Other academic) Published
Abstract [en]

Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype and allelic variation at human leukocyte antigen (HLA) class II loci to the risk of developing cervical carcinoma in situ. Non-European-like HPV 16 E6 sequence subtypes were not found to be associated with an increased risk of cervical carcinoma, as compared to European-like variants. However, an association was found between the HPV 16 E6 L83V variant and the DR*04-DQ*03 haplotype. This association has been observed in several independent studies and shows that both the host HLA class II genotype and viral subtype will affect the risk of an infection progressing into cervical carcinoma.

Place, publisher, year, edition, pages
2005. Vol. 117, no 4, 690-692 p.
Keyword [en]
cervical carcinoma, HLA, HPV 16 E6
Identifiers
URN: urn:nbn:se:uu:diva-73377DOI: 10.1002/ijc.21212PubMedID: 15929080OAI: oai:DiVA.org:uu-73377DiVA: diva2:101287
Available from: 2005-06-02 Created: 2005-06-02 Last updated: 2017-12-14Bibliographically approved

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Beskow, Anna H.Engelmark, Malin T.Magnusson, Jessica J.Gyllensten, Ulf B.

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