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An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Department of Medical Cell Biology. Neurobiology. (CNS Injury Research)
Department of Medical Cell Biology. Department of Surgical Sciences. Neurobiology. (CNS Injury Research)
Department of Medical Cell Biology. Department of Surgical Sciences. Neurobiology. (CNS Injury Research)
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2003 (English)In: Acta Neurochirurgica: Brain Edema XII Supplment, Vol. 86, 425-32 p.Article in journal (Other (popular scientific, debate etc.)) Published
Abstract [en]

The influence of the potent L-type Ca[2+] channel antagonist Nimodipine on spinal cord evoked potentials (SCEP) and axonal injury following trauma to the spinal cord was examined in a rat model. Spinal cord injury (SCI) was produced by an incision into the right dorsal horn of the T10-11 segments under urethane anaesthesia (1.5 g/kg, i.p.). SCEPs were recorded by epidural electrodes placed over the T9 (rostral) and T12 (caudal) segments after stimulation of the right tibial and sural nerves. SCI induced a pronounced decrease of the SCEP negative amplitude in the rostral (T9) recordings immediately after trauma. Axonal injury seen as degradation of myelin basic protein (MBP) immunostaining and myelin vesiculation at the ultrastructural level was most pronounced at 5 h. Continuous administration of Nimodipine (2 microg/kg/min, i.v.) from 30 min prior to injury until sacrifice markedly attenuated the changes in SCEP amplitude and latency. Axonal damage, loss of MBP, and myelin vesiculation were much less evident in the nimodipine treated traumatised rats. These observations suggest that Ca[2+] channels play an important role in the trauma induced alterations in SCEP and axonal injury, and indicate a therapeutic value of Ca[2+] blockers in SCI.

Place, publisher, year, edition, pages
2003. Vol. 86, 425-32 p.
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-73424PubMedID: PMID: 14753480OAI: oai:DiVA.org:uu-73424DiVA: diva2:101334
This article demonstrate that pretreatment with calcium channel antagonist, Nimodipine induces neuroprotection following 5 h spinal cord injury. Recording of evoked potential suggests that edema and cord pathology can be predicted earlier within 4 min of spinal cord injury.Available from: 2007-03-12 Created: 2007-03-12 Last updated: 2011-01-13

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Winkler, THari Shanker, SharmaErik, StålbergGordh, T
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