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Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Bioorganic Chemistry.
2003 (English)In: Org Biomol Chem, ISSN 1477-0520, Vol. 1, no 1, 81-92 p.Article in journal (Other scientific) Published
Place, publisher, year, edition, pages
2003. Vol. 1, no 1, 81-92 p.
Keyword [en]
Base Sequence, Cytidine/*chemistry, Deoxyribonuclease I/chemistry, Dose-Response Relationship; Drug, Electrophoresis; Polyacrylamide Gel, Endonucleases/*pharmacology, Ethers; Cyclic/*chemistry, Exonucleases/chemistry/*pharmacology, Humans, Kinetics, Models; Chemical, Molecular Sequence Data, Nucleic Acid Conformation, Nucleotides/pharmacology, Oligonucleotides; Antisense/*pharmacology, Protein Binding, RNA/chemistry, Research Support; Non-U.S. Gov't, Ribonuclease H; Calf Thymus/*chemistry, Temperature
Identifiers
URN: urn:nbn:se:uu:diva-73474PubMedID: 12929393OAI: oai:DiVA.org:uu-73474DiVA: diva2:101384
Available from: 2005-06-07 Created: 2005-06-07 Last updated: 2011-01-13

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Chattopadhyaya, Jyoti

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