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Effect of temperature history on the freeze-thawing process and activity of LDH formulations
Uppsala University.
Uppsala University.
1997 (English)In: PHARMACEUTICAL RESEARCH, ISSN 0724-8741, Vol. 14, no 4, 426-430 p.Article in journal (Other scientific) Published
Abstract [en]

Purpose. The purpose of the study was to investigate the effect of freeze-thawing processes with different temperature histories on thermal transformations and on protein activity of lactate dehydrogenase (LDH) formulations. Polyethylene glycol (PEG 6000)

Place, publisher, year, edition, pages
PLENUM PUBL CORP , 1997. Vol. 14, no 4, 426-430 p.
Keyword [en]
freeze-thawing; protein stability; oscillating DSC; lactate dehydrogenase; PEG; maltodextrin; NUCLEATION; GLYCOL; WATER; ICE
URN: urn:nbn:se:uu:diva-73498OAI: oai:DiVA.org:uu-73498DiVA: diva2:101408
Addresses: Alden M, UNIV UPPSALA, CTR BIOMED, DEPT PHARMACEUT CHEM PHYS & INORGAN CHEM, BOX 574, S-75123 UPPSALA, SWEDEN.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-15

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