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Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Teratology)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Teratology)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Teratology)
2005 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 54, no 2, 546-553 p.Article in journal (Refereed) Published
Abstract [en]

Maternal administration of folic acid diminishes the risk of neural tube defects (NTDs) in offspring, but whether folic acid exerts a similar effect in diabetic pregnancy is unknown. The aim was to investigate whether maldevelopment in rat embryos caused by exposure to diabetes in vivo or high-glucose concentrations in vitro is affected by subcutaneous administration of folic acid to the pregnant mother or by adding the compound to the culture medium, respectively. Exposure of embryos to maternal diabetes in vivo or 30 mmol/l glucose in vitro yielded an increased malformation rate (71 and 88% NTD, respectively) and lowered somite number and crown-rump length compared with control embryos. When we injected folic acid into the diabetic pregnant rat, or added 2 mmol/l folic acid to the culture medium with high glucose, the embryonic parameters improved (3 and 5% NTD, respectively). The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy.

Place, publisher, year, edition, pages
2005. Vol. 54, no 2, 546-553 p.
Keyword [en]
Abnormalities/*etiology/prevention & control, Animals, Diabetes Mellitus; Experimental/*pathology, Dietary Supplements, Female, Folic Acid/*therapeutic use, Glucose/*toxicity, Neural Tube Defects/etiology/prevention & control, Pregnancy, Pregnancy in Diabetics/*physiopathology, RNA/genetics/isolation & purification, Rats, Research Support; Non-U.S. Gov't, Tail/abnormalities/embryology
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73547DOI: 10.2337/diabetes.54.2.546PubMedID: 15677514OAI: oai:DiVA.org:uu-73547DiVA: diva2:101457
Available from: 2007-11-16 Created: 2007-11-16 Last updated: 2017-12-14Bibliographically approved

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Gäreskog, Mattias

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