uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Öron-, näs och hals)
2003 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 123, no 4, 459-465 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

OBJECTIVE: Apoptosis may play an important role in the mechanism of aminoglycoside ototoxicity. Caspases and calpains are regarded to be important factors in the regulation of cell death in the inner ear. We hypothesized that caspase or calpain inhibitors would protect hair cells from aminoglycoside ototoxicity. MATERIAL AND METHODS: In order to test this hypothesis we carried out a pilot study to determine if gentamicin (GM) would induce caspase and calpain immunolabeling in guinea pig hair cells Having confirmed this we carried out the main experiment using guinea pig vestibular organ culture to determine if caspase and calpain would protect the hair cells from GM ototoxicity. RESULTS: Immunoreactivity for caspase-3 and m-calpain was detected in the vestibular sensory cells and ganglia after GM treatment. Both caspase and calpain inhibitors protected hair cells against gentamicin ototoxicity. CONCLUSION: It is suggested that inhibition of apoptosis is essential in order to block aminoglycoside ototoxicity.

Place, publisher, year, edition, pages
2003. Vol. 123, no 4, 459-465 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73575PubMedID: 12797578OAI: oai:DiVA.org:uu-73575DiVA: diva2:101485
Available from: 2005-06-10 Created: 2005-06-10 Last updated: 2010-02-19Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Anniko, Matti
By organisation
Department of Surgical Sciences
In the same journal
Acta Oto-Laryngologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 197 hits
ReferencesLink to record
Permanent link

Direct link