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Lipophilicity in Drug Development: Too Much or Not Enough?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Teva Branded Pharmaceut R&D Inc, Dept Pharmaceut, W Chester, PA USA..
2016 (English)In: AAPS Journal, ISSN 1550-7416, E-ISSN 1550-7416, Vol. 18, no 5, 1095-1100 p.Article in journal (Refereed) Published
Abstract [en]

A round table discussion was held during the AAPS Annual Meeting on October 27, 2015, with the somewhat provocative topic of whether we need more or less lipophilic compounds in drug development. The session was attended by more than 250 participants, and the feedback was very positive as this round table became a forum for the exchange of ideas from scientists within the academia and industry. Most importantly, the discussion highlighted the difference in approaches to compound selection and development strategies in various companies and organizations. As moderators of this session, we are writing this report to highlight the points and counterpoints made at the session and to bring the importance of the dialogue and debate to the forefront of discussions on how to select the best drug development candidates to enable efficient delivery and, hence, treatment of diseases.

Place, publisher, year, edition, pages
2016. Vol. 18, no 5, 1095-1100 p.
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-304156DOI: 10.1208/s12248-016-9947-5ISI: 000382094200005PubMedID: 27393481OAI: oai:DiVA.org:uu-304156DiVA: diva2:1014911
Available from: 2016-10-03 Created: 2016-10-03 Last updated: 2016-10-03Bibliographically approved

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