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Radical scavengers for Ménière´s disease after failure of conventional therapy: A pilot study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
2003 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 123, no 6, 697-703 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

OBJECTIVE: To perform a trial to assess the efficacy of radical scavengers, i.e. rebamipide, vitamin C and glutathione, for the treatment of Ménière's disease (MD). MATERIAL AND METHODS: Rebamipide (300 mg/day), vitamin C (600 mg/day) and/or glutathione (300 mg/day) were given orally for at least 8 weeks to 25 patients with poorly controlled MD. RESULTS: Of 22 patients, 21 showed marked improvement of vertigo; 12/27 ears showed improvement of hearing disorders; 17/27 ears showed improvement of tinnitus; and 18/25 patients showed improvement of disability. CONCLUSION: This study suggests that treatment using radical scavengers has the potential to become an effective new therapy for MD.

Place, publisher, year, edition, pages
2003. Vol. 123, no 6, 697-703 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-73583PubMedID: 12953767OAI: oai:DiVA.org:uu-73583DiVA: diva2:101493
Available from: 2007-05-04 Created: 2007-05-04 Last updated: 2010-02-19Bibliographically approved

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