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Transmission of Neurodegenerative Disorders Through Blood Transfusion A Cohort Study
Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, SE-17177 Stockholm, Sweden..
Statens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark..
Statens Serum Inst, Dept Epidemiol Res, 5 Artillerivej, DK-2300 Copenhagen S, Denmark..
Univ Leicester, Dept Hlth Sci, Adrian Bldg,Univ Rd, Leicester LE1 7RH, Leics, England. Uppsala Univ, Dept Immunol Genet & Pathol, Akad Sjukhuset, SE-75185 Uppsala, Sweden..
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2016 (English)In: Annals of Internal Medicine, ISSN 0003-4819, E-ISSN 1539-3704, Vol. 165, no 5, 316-+ p.Article in journal (Refereed) Published
Abstract [en]

Background: The aggregation of misfolded proteins in the brain occurs in several neurodegenerative disorders. Aberrant protein aggregation is inducible in rodents and primates by intracerebral inoculation. Possible transfusion transmission of neurodegenerative diseases has important public health implications. Objective: To investigate possible transfusion transmission of neurodegenerative disorders. Design: Retrospective cohort study. Setting: Nationwide registers of transfusions in Sweden and Denmark. Participants: 1 465 845 patients who received transfusions between 1968 and 2012. Measurements: Multivariable Cox regression models were used to estimate hazard ratios for dementia of any type, Alzheimer disease, and Parkinson disease in patients receiving blood transfusions from donors who were later diagnosed with any of these diseases versus patients who received blood from healthy donors. Whether excess occurrence of neurodegenerative disease occurred among recipients of blood from a subset of donors was also investigated. As a positive control, transmission of chronic hepatitis before and after implementation of hepatitis C virus screening was assessed. Results: Among included patients, 2.9% received a transfusion from a donor diagnosed with one of the studied neurodegenerative diseases. No evidence of transmission of any of these diseases was found, regardless of approach. The hazard ratio for dementia in recipients of blood from donors with dementia versus recipients of blood from healthy donors was 1.04 (95% CI, 0.99 to 1.09). Corresponding estimates for Alzheimer disease and Parkinson disease were 0.99 (CI, 0.85 to 1.15) and 0.94 (CI, 0.78 to 1.14), respectively. Hepatitis transmission was detected before but not after implementation of hepatitis C virus screening. Limitation: Observational study design, underascertainment of the outcome, and possible insufficient statistical power. Conclusion: The data provide no evidence for the transmission of neurodegenerative diseases and suggest that if transmission does occur, it is rare.

Place, publisher, year, edition, pages
2016. Vol. 165, no 5, 316-+ p.
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Family Medicine
URN: urn:nbn:se:uu:diva-304152DOI: 10.7326/M15-2421ISI: 000382795000002PubMedID: 27368068OAI: oai:DiVA.org:uu-304152DiVA: diva2:1014941
Swedish Research Council, 2011-30405 2007-7469Swedish Heart Lung Foundation, 20090710Swedish Society for Medical Research (SSMF)Danish National Research Foundation, 2009B026
Available from: 2016-10-03 Created: 2016-10-03 Last updated: 2016-10-03Bibliographically approved

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