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Heat shock protein 70 delays gentamicin-induced vestibular hair cell death
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Earn-Nose-Throat)
2005 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 125, no 7, 23-28 p.Article in journal (Refereed) Published
Abstract [en]

In this study, geranylgeranylacetone (GGA) was shown to induce heat shock protein (HSP)70 in the vestibular end organs of the guinea pig and to alleviate gentamicin (GM) ototoxicity. This was accomplished without thermal preconditioning. In isolated guinea pig vestibular end organs we demonstrated possible prophylactic (preventive) effects of GGA on GM ototoxicity by actively inducing HSP70. When HSP70 was pre-incubated with GGA, its content in sensory cell cytoplasm and transitional dark cells was increased. Pre-incubation of vestibular end organs with GGA gave sensory cells partial protection from GM toxicity. These findings show that administration of GGA can protect vestibular sensory cells from GM ototoxicity and suggest that induction of HSP70 by GGA may be a useful adjunct for the treatment of vestibular disorders.

Place, publisher, year, edition, pages
2005. Vol. 125, no 7, 23-28 p.
Keyword [en]
Animals, Anti-Bacterial Agents/*adverse effects/*antagonists & inhibitors, Cell Death/drug effects, Fluorescence, Gastric Mucosa/blood supply/drug effects, Gentamicins/*adverse effects/*antagonists & inhibitors, Guinea Pigs, HSP70 Heat-Shock Proteins/pharmacokinetics/*pharmacology, Hair Cells/*drug effects/metabolism, Immunohistochemistry, Vestibule/*drug effects/metabolism
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73586DOI: 10.1080/00016480410017495PubMedID: 15799569OAI: oai:DiVA.org:uu-73586DiVA: diva2:101496
Available from: 2008-02-19 Created: 2008-02-19 Last updated: 2017-12-14Bibliographically approved

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Anniko, Matti

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