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[111In-DPTA-D-Phe1] - Octreotide Scintigraphy in the Management of Patients with Advanced Renal Cell Carcinoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
(Uppsala University Pet-Centre)
(Uppsala University Pet-Centre)
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1999 (English)In: Cancer Biotherapy and Radiopharmaceuticals, ISSN 1084-9785, E-ISSN 1557-8852, Vol. 14, no 1, 59-64 p.Article in journal (Other academic) Published
Abstract [en]

Somatostatin receptor scintigraphy using the 111In-labelled somatostatin analogue octreotide (Octreoscan) was performed in 9 patients with metastatic renal cell carcinoma. In total 11 scintigraphies were performed. Positive tumor uptakes were observed in 9 patients. The results of the octreotide scans were correlated to diagnostic CT and/or X-ray images. Forty (59%) out of 68 known tumor localizations were visualized with the octreotide scan. A second scan following therapy was performed in two patients. These patients showed progressive disease despite treatment and also exhibited intensified uptakes at octreotide scintigraphy. One false positive lesion was observed in the 40 lesions visualized in scintigraphy.

It was concluded that renal cell carcinoma expresses somatostatin receptors, as could be visualized with Octreoscan scintigraphy. The scintigraphic technique can be used as an instrument for in vivo characterization of the disease. The data could also form a basis for future investigations regarding the possible therapeutic effect of octreotide in the management of renal cell cancer.

Place, publisher, year, edition, pages
1999. Vol. 14, no 1, 59-64 p.
Keyword [en]
Aged, Carcinoma; Renal Cell/pathology/radiography/*radionuclide imaging, Comparative Study, Disease Progression, Evaluation Studies, Female, Humans, Indium Radioisotopes/*diagnostic use, Kidney Neoplasms/pathology/radiography/*radionuclide imaging, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Proteins/*analysis, Receptors; Somatostatin/*analysis, Research Support; Non-U.S. Gov't, Somatostatin/*analogs & derivatives/diagnostic use, Tomography; X-Ray Computed, Tumor Markers; Biological
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Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-73667DOI: 10.1089/cbr.1999.14.59PubMedID: 10850288OAI: oai:DiVA.org:uu-73667DiVA: diva2:101577
Available from: 2005-06-13 Created: 2005-06-13 Last updated: 2014-09-11Bibliographically approved

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Edgren, MalihaSundin, AndersNilsson, Sven

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