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Increased serum cyststin C is associated with increased mortality in elderly men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biokemisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
2005 (Swedish)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 65, no 4, 301-305 p.Article in journal (Refereed) Published
Abstract [en]

Renal dysfunction measured by serum creatinine is associated with increased cardiovascular morbidity and mortality. Plasma cystatin C has been shown in several studies to be superior to plasma creatinine for the estimation of glomerular filtration rate (GFR). The aim of the present study was to investigate the relationship between cystatin C and mortality in elderly men. Serum cystatin C was analyzed by nephelometry in a group of 77-year-old men (n=792) and correlated cystatin C levels with mortality during a follow-up period of 1-4 years. The cystatin C values were significantly correlated with overall mortality (p=0.013). Mortality was three times higher in the highest cystatin C quintile in relation to the lowest quintile.

Place, publisher, year, edition, pages
2005. Vol. 65, no 4, 301-305 p.
Keyword [en]
Aged, Biological Markers/*blood, Cohort Studies, Cystatins/*blood, Glomerular Filtration Rate, Humans, Kidney Failure; Chronic/*blood/*mortality, Male, Nephelometry and Turbidimetry, Prognosis, Risk Factors
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-73746DOI: 10.1080/00365510510013839PubMedID: 16076685OAI: oai:DiVA.org:uu-73746DiVA: diva2:101656
Available from: 2007-03-08 Created: 2007-03-08 Last updated: 2017-12-14Bibliographically approved

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Larsson, AndersHelmersson, JohannaBasu, Samar

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