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Increased Dopamine Content in Lymphocytes from High-Dose L-Dopa-Treated Parkinson's Disease Patients
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Analytisk kemi.
2005 (English)In: Neuroimmunomodulation, no 12, 81-84 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The intracellular (i.c) content of dopamine and its metabolites was measured in the peripheral blood lymphocytes (PBLs) of Parkinson's disease (PD) patients and healthy controls. Methods: Catecholamine levels of PBLs were measured using capillary electrophoresis in healthy controls and PD patients receiving different doses of L-dihydroxyphenylalanine (L-Dopa). Results: Higher i.c. dopamine content was found in lymphocytes from PD patients receiving a high dose of L-Dopa (700 +- 30 mg/day) as compared to lymphocytes from the healthy controls (p = 0.002) and from PD patients treated with a low dose of L-Dopa (400 +- 30 mg/day) (p = 0.022). The dihydroxyphenylacetic acid to dopamine ratio was significantly lower in the high-dose L-Dopa-treated PD patients than in the controls (p = 0.013). Conclusions: These findings suggest that the dopamine content and metabolism in the peripheral lymphocytes of PD patients are influenced by L-Dopa administration. This is the first study in which a dose-related effect of L-Dopa treatment was found in lymphocytes from PD patients.

Place, publisher, year, edition, pages
2005. no 12, 81-84 p.
Keyword [en]
Capillary electrophoresis, Catecholamine, Dopamine, Parkinson's disease, Peripheral blood lymphocytes
URN: urn:nbn:se:uu:diva-73853OAI: oai:DiVA.org:uu-73853DiVA: diva2:101764
Available from: 2005-07-07 Created: 2005-07-07 Last updated: 2011-01-11

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