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Epithelial Cells and Their Neighbors: II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology. Fysiologi. (Intestinal)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiology. Fysiologi. (Intestinal)
2005 (English)In: American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, E-ISSN 1522-1547, Vol. 289, no 3, G377-G380 p.Article in journal (Refereed) Published
Abstract [en]

Surface sensory enteroendocrine cells are established mucosal taste cells that monitor luminal contents and provide an important link in transfer of information from gut epithelium to the central nervous system. Recent studies now show that these cells can also mediate efferent signaling from the brain to the gut. Centrally elicited stimulation of vagal and sympathetic pathways induces release of melatonin, which acts at MT(2) receptors to increase mucosal electrolyte secretion. Psychological factors as well mucosal endocrine cell hyperplasia are implicated in functional intestinal disorders. Central nervous influence on the release of transmitters from gut endocrine cells offers an exciting area of future gastrointestinal research with a clinical relevance.

Place, publisher, year, edition, pages
2005. Vol. 289, no 3, G377-G380 p.
Keyword [en]
intestinal enterochromaffin cells, IBS, melatonin, orexin, uroguanylin
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-73947DOI: 10.1152/ajpgi.00093.2005OAI: oai:DiVA.org:uu-73947DiVA: diva2:101858
Available from: 2005-08-15 Created: 2005-08-15 Last updated: 2014-09-24Bibliographically approved

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Flemström, GunnarSjöblom, Markus

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